CORDIS Project
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This project investigates the molecular mechanisms of thyroid hormone synthesis in vertebrates, focusing on iodination of thyroglobulin, endocytosis, and storage processes. By employing advanced imaging techniques, the research aims to enhance understanding of hormone regulation and potentially inform new therapeutic s…
Metabolic functions in vertebrates are ruled by thyroid hormones, produced by the thyroid gland and secreted into the bloodstream.
Thyroid hormone levels modulate growth, development and many other key processes across the lifespan, and their impairment severely affects human health.
Despite extensive studies, controlling hormone levels in vivo remains a major challenge.
Synthesis of thyroid hormones occurs extracellularly, via iodination of thyroglobulin.
They must then undergo endocytosis befo…
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