CORDIS Project
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This project aims to develop methods for visualizing transient conformations of protein complexes using time-resolved single particle cryogenic electron microscopy. By freeze-trapping kinetic intermediates, the project seeks to provide atomic-resolution insights into the functioning of molecular machines, particularly…
Protein synthesis and degradation, energy metabolism, signalling, processing of information-encoding polymers (RNA and DNA) are facilitated and regulated by molecular machines, protein complexes that undergo significant conformational changes in time as they facilitate their function.
To be able to control the biological processes rationally and with high precision it is essential to understand their mechanism at atomic level. A powerful way to gain detailed insight onto function of these protei…
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