CORDIS Project
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The TI-LAB project investigates how immune complexes formed by therapeutic antibodies and Pseudomonas aeruginosa can induce trained immunity in lung macrophages. By exploring the underlying molecular mechanisms, the project aims to enhance protection against respiratory infections and potentially improve treatments for…
Therapeutic antibodies (Abs), have become crucial drugs in modern medicine, showing success in treating various diseases, including the global COVID-19 pandemic.
Although anti-infective Abs are usually administered parenterally, recent findings demonstrated that local administration into the respiratory tract of an Ab neutralizing Pseudomonas aeruginosa (Pa) not only blocks primary infection but also offers prolonged protection against secondary infections.
However, the molecular mechanisms supp…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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France, Tours
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Netherlands, NIJMEGEN
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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