CORDIS Project
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This project is developing a novel protein-based tool to non-invasively control neuronal activity, targeting chronic pain treatment. The approach utilizes temperature-regulated potassium channels to inhibit neuron firing without side effects.
Non-invasive Control of Neuronal Activity can in principle contribute to the medical treatment of pathologic states in which the electrical activity of neurons is impaired, as in seizures and in chronic pain (CP).
To this end, we are developing and validating proteins regulated by non-toxic external stimuli that freely penetrate tissues. TICK (Temperature InduCed K+ channel) is a K+ Channel reversibly regulated by Temperature in a very narrow range (37-40 °C).
The open channel drives a large K+…
UNIVERSITA DEGLI STUDI DI MILANO
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