CORDIS Project
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This project investigates glucocorticoid resistance in T-cell acute lymphoblastic leukemia, focusing on the NOTCH1 signaling pathway. It aims to identify new genes and develop targeted therapies to overcome resistance and improve treatment outcomes for this aggressive cancer.
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer that accounts for 10% to 15% of pediatric and 25% of adult ALL cases.
Glucocorticoids play a central role in the treatment of T-ALL due to their capacity to induce growth arrest and apoptosis in lymphoid progenitor cells.
The development of glucocortioid resistance in leukemia patients is an important clinical problem and a significant contributor to therapeutic failure.
Despite numerous studies addressing the mechan…
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