CORDIS Project
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This project focuses on engineering new catalytic functions into the TIM-barrel protein structure, which is prevalent in nature and known for its ability to facilitate various chemical reactions. Using advanced gene shuffling techniques, the research aims to enhance the versatility of this protein scaffold for potentia…
The TIM-barrel fold is the most widely found in nature, making up about 6% of the structures in the Protein Data Bank, and has been found in nature to catalyse reactions from five of the six EC classes.
These facts all indicate the extraordinary capacity of the TIM-barrel as a reaction container, and suggest that it may be a versatile starting scaffold into which new catalytic capability can be engineered.
In this research programme we will use directed evolution approaches, including state-of-t…
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