CORDIS Project
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This project focuses on understanding the mechanisms of posttranscriptional gene silencing in plants, particularly the assembly of RNA-induced silencing complexes. It utilizes a cell-free system to investigate the roles of various proteins in gene regulation and the effects of viral suppressors on antiviral responses.
Posttranscriptional gene silencing (PTGS) is a form of small (s)RNA-mediated gene regulation with important roles in development, stress responses, and antiviral defense in plants.
PTGS effectors, called RNA-induced silencing complexes (RISCs), have ARGONAUTE (AGO) proteins bound to single-stranded (ss) guide sRNAs as core components.
RISCs recognize target RNA displaying complementarity to guide sRNAs, and inactivate them by endonucleolytic cleavage (or ‘slicing’) or by slicer-independent trans…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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