CORDIS Project
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This research explores the interaction between microRNAs and chromatin factors in stem cells, focusing on their role in gene regulation during differentiation. It aims to uncover mechanisms that could inform targeted therapies for diseases.
Both epigenetic factors and microRNAs have the potential to control transcript levels of large sets of genes through transcriptional and post-transcriptional mechanisms.
Faithful stem cell function is crucial for tissue maintenance and repair throughout life and requires these machineries to establish specific and dynamic transcription programs.
However, how miRNAs and chromatin-factors cooperate to achieve this is poorly characterized. I previously developed genetic screening and computational…
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