CORDIS Project
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This project investigates the formation and function of Tertiary Lymphoid Structures (TLS) in chronic inflammation and autoimmune diseases. By analyzing cell interactions and signaling pathways through advanced sequencing techniques, it aims to enhance understanding of TLS biology and its potential therapeutic applicat…
Formation of Tertiary Lymphoid Structures (TLS) is a recurring consequence of chronic tissue inflammation and autoimmunity, as well as several solid tumours. TLS originate in various tissues from infiltrating cells attracted by local signalling cascades.
These structures can enhance local immune response by, similarly to Secondary Lymphoid Organs (SLO), functioning as spots for lymphocyte activation upon antigen recognition.
However, the cellular interactions driving TLS emergence and function a…
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