CORDIS Project
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This project explores the regulation of Toll-like receptors 7 and 9, which recognize nucleic acids and can influence autoimmune diseases. It employs advanced microscopy to study their cellular dynamics and signaling pathways.
Recognition of nucleic acids enables detection of diverse pathogens by a limited number of innate immune receptors, but also exposes the host to potential autoimmunity.
At least two members of the Toll-like receptor (TLR) family, TLR7 and TLR9, can recognize self-RNA or DNA, respectively, and contribute to the pathology of autoimmune diseases.
Despite the structural and functional similarities between these two receptors, they can have opposing effects in autoimmune diseases such as systemic lup…
FREIE UNIVERSITAET BERLIN
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