CORDIS Project
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This project investigates the role of tumor-associated macrophages in cancer progression and immune evasion. It focuses on understanding the signaling pathways that promote a pro-tumor phenotype in macrophages, aiming to restore their anti-tumor functions for therapeutic purposes.
There is increasing evidence that the body s ability to mount an immune response to cancer cells may dictate which patients are cured of cancer by conventional therapy.
Macrophages have a central role in both innate and adaptive immunity; both human and experimental cancers become infiltrated by macrophages, however tumour-associated macrophages (TAM) are corrupted by the tumour microenvironment to promote survival, invasion and metastasis of cancer cells. TAM also contribute to immune-suppressi…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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