CORDIS Project
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This project investigates the role of myristoylation in Tumour Necrosis Factor-alpha (TNFa) signaling and its impact on other cytokines. By employing advanced chemical biology and proteomics, the research aims to enhance understanding of cytokine behavior and identify potential therapeutic targets for autoimmune disord…
Tumour Necrosis Factor-alpha (TNFa) is an important cytokine implicated in many autoimmune and inflammatory disorders, in which TNFa-blocking antibody drugs have become first line treatment.
Nevertheless, clinical responses are variable.
To improve and expand therapeutic strategies, a better understanding of TNFa and the many other cytokines secreted from cells is crucial.
It was recently shown that TNFa is myristoylated on a lysine residue (KMyr), a unique modification that suggests an importan…
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