CORDIS Project
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This research aims to improve the detection of the Tn antigen, a cancer biomarker, by evolving a specific lectin probe. The project utilizes phage display technology to enhance the probe's selectivity and affinity, facilitating better diagnostics and potential vaccine development for cancer and HIV.
Major changes in carbohydrate expression occur during the onset and progression of cancer.
These alterations in glycosylation may result in both the loss of normal carbohydrate antigens (e.g. ABO blood group antigens) and/or high expression of carbohydrate structures that normally have low or restricted expression in healthy adults.The Tn antigen is expressed in most carcinomas, during embryogenesis, on pathogenic parasites, and on HIV, yet its expression is rare in normal adult tissue, creating…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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