CORDIS Project
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This project focuses on discovering new drug compounds targeting orphan G protein-coupled receptors, specifically GPR3, GPR6, and GPR12, which are involved in various diseases including neurodegenerative disorders and cancer. By combining computational methods with advanced biosensor technology, the project aims to enh…
The family of G protein-coupled receptors (GPCRs) comprises more than 800 human cell surface receptors that perceive and transmit extracellular stimuli into the cell interior.
Due to their involvement in numerous biochemical processes, GPCRs represent prime targets for the treatment of various diseases and are modulated by more than 30% of approved drugs today.
However, a large proportion of the druggable GPCRome remains pharmacologically untapped, including the so-called ‘orphan’ GPCRs (oGPCRs)…
PHILIPPS UNIVERSITAET MARBURG
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