CORDIS Project
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This project investigates the role of electrical synapses formed by connexin channels in the central nervous system, focusing on hypothalamic neurons in rats and mice. By examining how these connections influence neuronal activity and behavior, particularly in male parenting, the research aims to uncover the mechanisms…
The complex network activity patterns of the CNS result from an interplay between intrinsic neuronal properties and the connections formed by component cells.
Connectivity is most commonly considered in terms of the classical chemical synapse.
It is now clear, however, that electrical synapses formed by intercellular connexin channels in gap junctions (GJs) are widespread in the mammalian CNS and critically influence circuit activity.
But exactly how GJs shape brain output, and how electrical co…
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