CORDIS Project
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This project aims to develop advanced imaging technology to study cAMP signaling triggered by individual cell surface receptors. By creating highly sensitive sensors and specialized microscopy, the research will explore the quantal nature of cAMP signals in various biological systems, enhancing our understanding of rec…
Most drugs act via cell surface receptors.
Some receptors signal to ion channels, while others regulate 2nd messengers, most importantly cAMP.
Ion channels can be resolved at the single channel level using patch clamp analysis; they switch between discrete "on" and "off" states.
In contrast, current techniques to analyze cAMP-signals are quite global and generally require destruction of the sample.
Therefore, the activation mechanisms and switching behaviour of receptors signalling to cAMP are l…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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