CORDIS Project
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This project focuses on understanding the repair mechanisms of DNA damage caused by topoisomerases, which are crucial for chromosome stability. It aims to explore the implications of these processes for cancer treatment and neurodegenerative diseases using various biological techniques.
DNA topoisomerases are conserved nuclear enzymes that regulate DNA topology by transiently cleaving and resealing the DNA molecule, fulfilling a fundamental role in virtually every aspect of chromosome metabolism.
Nevertheless, erroneous or abortive topoisomerase activity can result in persistent DNA strand breaks with the enzyme covalently attached to 3’ or 5’ DNA ends by a phosphotyrosyl bond, an anomalous structure that can compromise cell survival and/or genome integrity with the consequent…
UNIVERSIDAD DE SEVILLA
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