CORDIS Project
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This project investigates the cellular mechanisms that repair DNA damage caused by topoisomerase II inhibitors, such as etoposide, which are used in cancer treatment. By utilizing Xenopus egg extracts, the research aims to clarify how the enzyme ZATT regulates the repair processes, potentially leading to improved cance…
Topoisomerase II (TOP2) chemotherapeutics such as etoposide have been widely used in the clinic to treat leukemias, lymphomas, lung, testicular, and ovarian cancers.
Etoposide was first approved for clinical usage in 1983.
By intercalating into DNA, etoposide stalls the TOP2 catalytic cycle, generating toxic DNA lesions known as TOP2-DNA-protein crosslinks (TOP2-DPCs).
After 40 years of intense research, the mechanisms employed by cells that counteract these lesions are starting to emerge.
These…
KOBENHAVNS UNIVERSITET
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