CORDIS Project
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This project focuses on developing advanced techniques to analyze the interactions between sister chromatids in eukaryotic genomes. By employing a new method called sister chromatid-sensitive Hi-C, the research aims to create detailed maps of chromosomal structures, enhancing our understanding of DNA repair, gene regul…
Topological interactions between distant DNA segments play fundamental roles in the function of eukaryotic genomes.
While tremendous progress has been made in understanding the molecular mechanisms shaping intramolecular chromosome loop structures, limitations in our ability to distinguish specific chromosome conformations between paired molecules has hindered research into the role of interactions across separate chromosomal DNA molecules.
Our recent development of an approach allowing analysis…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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