CORDIS Project
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This project investigates the role of DNA topoisomerases in managing DNA structure and their implications for cancer therapy and neurological diseases. By developing innovative assays, the project aims to understand how these enzymes induce DNA breaks and how cells repair these damages, which is crucial for genome inte…
DNA topoisomerases are conserved nuclear enzymes that regulate DNA topology by transiently cleaving and resealing the DNA molecule, fulfilling a fundamental role in virtually every aspect of chromosome metabolism.
Nevertheless, erroneous or abortive topoisomerase activity can result in persistent DNA strand breaks with the enzyme covalently attached to 3’ or 5’ DNA ends by a phosphotyrosyl bond, an anomalous structure that can compromise cell survival and/or genome integrity with the consequent…
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