CORDIS Project
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This project investigates the mechanics of DNA replication, focusing on how torque and twist affect the activity of the replisome. By utilizing advanced single-molecule techniques, the research aims to uncover the dynamics of DNA replication and its implications for understanding human diseases.
The replication of DNA is one of the fundamental processes that drives all life.
Errors in replication are responsible for a host of human diseases as well as for all adaptation and evolution, and hence the mechanisms, regulation, and fidelity of this process are of great interest to both fundamental biology and medical research. A complete, active replisome was recently reconstituted in yeast, allowing unprecedented probing and control of eukaryotic DNA replication in in vitro experiments.
In t…
TECHNISCHE UNIVERSITEIT DELFT
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