CORDIS Project
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This project explores the Target Of Rapamycin (TOR) proteins and their role in cellular homeostasis. By identifying feedback loops in TOR signaling networks, it aims to clarify how these proteins regulate metabolism and maintain cellular balance, with implications for treating various diseases.
The Target Of Rapamycin (TOR) proteins are ser/thr kinases conserved in Eukarya.
They nucleate two distinct multiprotein complexes, named TORC1 and TORC2, which regulate many, widely varying, aspects of cell and organism physiology. TOR inhibitors, such as rapamycin and derivatives, are used clinically to treat cancer, cardio-vasculature disease and to prevent organ rejection.We recently reported that both TORC1/2 are wired in feedback loops, where their downstream cellular effectors are at the…
UNIVERSITE DE GENEVE
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