CORDIS Project
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This research focuses on understanding the molecular mechanisms that enable the transformation of gametes into totipotent zygotes in mice. It aims to identify key transcription factors and chromatin regulators involved in early embryonic development.
In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism.
It coincides with translation and degradation of maternally provided transcripts, initiation of global transcription called zygotic genome activation (ZGA), and “epigenetic reprogramming” of germline chromatin states into an embryonic state.
The molecular mechanisms underlying this exquisite reprogramming of cell fate are barely understood.
This research program…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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