CORDIS Project
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This project investigates the epigenetic mechanisms that restore totipotency shortly after fertilization in mammalian development. By studying early embryonic-like cells, it aims to enhance understanding of gene expression regulation and improve somatic reprogramming techniques for applications in regenerative medicine…
One of the most critical epigenetic and chromatin remodelling processes in mammalian development occurs shortly after fertilization restoring totipotency.
Due to limited cell numbers and lack of experimentally tractable systems, the mechanisms and regulation of this developmental stage are poorly understood.
This proposal will provide important mechanistic insights into the epigenetic control of early embryonic gene expression, and its relevance to somatic reprogramming.
Murine embryonic stem ce…
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