CORDIS Project
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This project explores the factors influencing the misfolding of the alpha-synuclein protein, which is linked to Parkinson's disease. By studying its interactions with lipid membranes, the research aims to understand how aging and disease affect protein aggregation.
Proteins are among the most essential molecules of life.
In order to fulfil their native function(s) they need to adopt a well-defined three-dimensional structure.
However, under some circumstances, proteins can misfold and/or form toxic amyloid structures, which are the hallmark of a range of diseases including type 2 diabetes and neurodegenerative diseases.
In particular, the small pre-synaptic protein, alpha-synuclein (AS), whose aggregation is the hallmark of Parkinson’s disease, can adopt i…
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
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