CORDIS Project
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This project investigates how messenger RNA translation is regulated during early development in the roundworm C. elegans. By employing advanced imaging and profiling techniques, it aims to map translation efficiencies and understand the mechanisms that dictate protein expression in specific cell types.
The translation of mRNAs by ribosomes is a key step in decoding the information stored in our genome.
Animal development requires a strict regulation of translation, in particular when transcription is absent, as in most early embryos. A range of mechanisms ensure that mRNAs are translated with the right efficiency and location, in the right cell types and exactly when their protein products are needed.
Disruption of this regulation can lead to developmental defects and embryonic lethality.
Desp…
UNIVERSITEIT UTRECHT
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