CORDIS Project
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This project seeks to develop a method for converting adult human cells into insulin-producing beta cells through the expression of specific transcription factors. This approach aims to address the shortage of donor organs for diabetes treatment.
Type 1 diabetes mellitus affects an estimated 0,5% of the world population.
Autoimmune rejection results in destruction of the insulin producing beta cells of the pancreas, leading to both acute and long term complications.
Daily injection of exogenous insulin allows long term managment of the condition, but does not avoid long term complications.
Reconstitution of the beta cell compartment by pancreas or cadaveric islet transplantation is heavily restricted by shortage of donor material and imm…
UNIVERSIDADE DO ALGARVE
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