CORDIS Project
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This project focuses on developing synthetic compounds that facilitate chloride transport across cell membranes, addressing issues related to cystic fibrosis and apoptosis. By synthesizing new transporter agents and testing their effectiveness in live cells, the project aims to establish a systematic method for screeni…
The regulation of cellular ion concentrations is critical for a range of physiological processes.
Malfunction of transmembrane Cl-/HCO3- antiport has been associated with cystic fibrosis and other channelopathies.
Changes in pH via H+/Cl- symport cause deacidification of acidic organelles leading to cytoplasmic acidification, an early event in apoptosis.
Synthetic anion transporters have been studied mainly in artificial vesicles for their ability to facilitate Cl-/HCO3- antiport and H+/Cl- symp…
UNIVERSITY OF SOUTHAMPTON
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