CORDIS Project
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This project focuses on understanding the regulation of Major Histocompatibility Complex (MHC) molecules, which are crucial for immune function. By studying specific proteins involved in MHC transcription, the research aims to uncover new pathways that could lead to therapeutic advancements for immune disorders.
MHC molecules are central to our immune system and are therefore also involved in several pathologies. MHCII transcription is controlled by proximal promoter sequences, which are cooperatively bound by several factors forming the ‘MHC enhanceosome’.
Upon recruitment to this complex, the NLR family member CIITA promotes MHCII transcription.We recently found that our mice deficient for the NLR NLRC5 exhibit markedly reduced MHCI expression in lymphocytes.
Importantly, endogenous NLRC5 occupies H-2…
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