CORDIS Project
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This project investigates how human cells respond to oxidative stress by examining changes in gene transcription. It aims to uncover the mechanisms behind transcriptional repression and activation, focusing on RNA polymerase II modifications and their implications for diseases like cancer and neurological disorders.
Environmental stress triggers a cellular response to promote adaptation and survival, typically through activation of stress genes.
What is less appreciated is that various types of cellular stress at the same time induce widespread transcriptional repression at most other genes.
Although such transcriptional reprogramming is common to various kinds of cellular stress, recent evidence suggests it is governed by different stress-specific mechanisms. A brief exposure to oxidative stress leads to a…
KOBENHAVNS UNIVERSITET
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