CORDIS Project
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This project aims to enhance gene therapy delivery using cationic lipids as non-viral vectors. By optimizing the interaction between these lipids and DNA, the research seeks to improve the efficiency of gene transfer into cells, particularly for therapeutic applications.
Cationic lipids (CL) are the most promising candidates for efficient and safe gene-delivery vectors for gene therapy.
Compared with viral capsids, CLs do not induce a response from the immune system.
Moreover, while viral capsids have a maximum DNA-carrying capacity of about 40 kbp, CLs, which form self-assemblies with distinct lamellar LαC and inverted hexagonal HIIC, or HIC nanostructures when complexed with DNA, place no limit on the size of the DNA.Despite all these promises, transfection ef…
MAX IV Laboratory, Lund University
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