CORDIS Project
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This project aims to elucidate the mechanisms of gene transcription regulation in eukaryotic cells, focusing on the initiation complex involving RNA polymerase II and the Mediator. By determining structural details and developing new techniques for measuring mRNA synthesis, the research seeks to enhance understanding o…
The regulation of gene transcription governs eukaryotic cell growth and differentiation.
Despite its importance, transcription regulation is not understood at a mechanistic level.
Regulation occurs mainly during initiation, when the enzyme RNA polymerase II (Pol II) assembles with ~50 polypeptides on promoter DNA.
Regulatory signals are transmitted by the 25-subunit Mediator, and convert the initiation complex into a productive elongation complex.
Ten years after the solution of the Pol II struc…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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Germany, MUNCHEN
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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