CORDIS Project
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This project investigates the role of transfer RNA in regulating gene expression during the development of the cerebral cortex. By examining how translation affects neuronal diversity, it aims to provide insights into the mechanisms of neurodevelopment and potential implications for neurological disorders.
The cerebral cortex with its range of specialized excitatory projection neurons is essential to the high-order cognitive functions of the brain.
These hundreds of subtypes of projection neurons arise from a uniform pool of multipotent apical progenitors (APs) which sequentially generate neuronal progeny with distinct fates over time.Recent technological advances in single cell transcriptomics revealed the existence transcriptional programs that seed neuronal diversity.
While this working model p…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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