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TRANSLATOME investigates the regulation of protein synthesis across different cellular conditions, focusing on how translation affects cancer progression. The project aims to identify translation modules and their mechanisms, specifically in breast cancer and glioblastoma, to inform potential treatment strategies.
The gene expression pathway includes transcription, mRNA translation, and protein degradation.
Altered translation can rapidly modulate protein levels, without requiring changes in transcription, and can therefore efficiently control cellular responses.
Despite evidence of key roles for transcript-selective modulation of translation, the extent and organization of translational control at a transcriptome-wide level is largely uncharted.
Moreover, major cancer types appear to be under strong post…
KAROLINSKA INSTITUTET
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