CORDIS Project
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This project addresses challenges in tissue engineering by optimizing nutrient delivery through perfusion bioreactors while minimizing harmful mechanical stresses on cells. It combines computational modeling with laboratory experiments to enhance cell viability and function in engineered tissues.
Difficulties encountered in tissue engineering invited the use of perfusion bioreactors to deliver essential nutrients to cells within tissue-engineered constructs.
Despite the increased nutrient transport achieved, solute perfusion caused harmful mechanical stresses to the cells.
Interestingly, some bioreactors are employed to mechanically stimulate cells, improving their biological functions.
However, stresses associated with perfusion bioreactors are counterproductive.
Currently, to address t…
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