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The TRANSPLIC project investigates the trans-splicing process in mRNA, where exons from different precursors merge. Using the model organism Trypanosoma brucei, it aims to reveal the molecular structures and mechanisms of trans-spliceosomes, enhancing our understanding of this critical mRNA processing step.
Trans-splicing is an essential mRNA processing step for a significant portion of living organisms.
In trans-splicing, exons from two pre-mRNA precursors merge into a single mRNA, while cis-splicing rearranges exons within the mRNA.
Despite recent technical advancements in cryo-electron microscopy (cryo-EM) that movie-like resolved different stages of cis-splicing, the trans-splicing mechanism is still a black box: input and output are defined, but the single steps of how the trans-spliceosome as…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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