CORDIS Project
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This project investigates genetic variations in specific transporter proteins that affect drug absorption and metabolism. By identifying these variants, the project aims to enhance personalized medicine approaches in drug therapy, improving efficacy and reducing adverse effects for various medications, particularly in…
The response to drug therapy varies widely between individuals.
Proteins involved in the absorption, distribution, metabolism and excretion of drugs play a central role in determining the concentration of a drug at the target site, and thus drug efficacy and toxicity.
Transporters are membrane proteins that mediate the translocation of chemicals into and out of cells using active and passive mechanisms.
We have identified a single nucleotide variant in the SLCO1B1 gene encoding the organic anion…
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