CORDIS Project
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This research explores the role of ancient viral elements, known as retrotransposons, in mammalian genomes. It aims to understand how these elements influence gene regulation and genome remodeling during critical developmental processes using advanced gene editing techniques.
Retrotransposons (RTNs) are ancient viruses that have stably integrated themselves into mammalian genomes and they now occupy around half of the human or mouse genome.
These mobile genetic elements that have coevolved with us drive evolution by creating new genes and plasticity of genomes.
Exciting data including ours has shown that even RTNs that are no longer active retain enhancer, promoter or repressor sequences that regulate developmental genes, through largely uncharacterized transcription…
QUEEN MARY UNIVERSITY OF LONDON
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United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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