CORDIS Project
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This project aims to develop targeted therapies for tumors with specific genetic mutations in tumor suppressor genes. By inducing the production of full-length proteins from nonsense mutations, the research seeks to restore normal cellular function and improve treatment outcomes for cancer patients.
Tumor suppressor genes such as TP53, RB1, PTEN and APC are frequently inactivated in sporadic and inherited human tumors. A significant fraction of the mutations in these genes are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional proteins.
We will identify and characterize novel molecules that can induce translational read-through of premature termination codons in nonsense mutant TP53 and expression of full length p53 p…
KAROLINSKA INSTITUTET
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