CORDIS Project
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This project aims to deepen the understanding of RNA Polymerase, the enzyme responsible for gene transcription. It focuses on how transcription factors influence RNA Polymerase dynamics, utilizing advanced structural and biochemical techniques.
During the first step of gene expression, a universally conserved enzyme called RNA Polymerase (RNAP) transcribes RNA from a DNA template in every cell.
Transcription is a fundamental, yet incompletely understood process.
Because of its central role, the bacterial transcription machinery is also a prime drug target.
Crystal structures of RNAP core as well as RNAP elongation complexes (ECs) have revolutionized our understanding of transcription.
This groundwork paved the way to address more compl…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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