CORDIS Project
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This project investigates the molecular mechanisms underlying Huntington's disease by analyzing RNA processing and transcriptional changes in affected brain regions. The goal is to understand how these alterations contribute to neuronal vulnerability and disease progression.
Huntington’s disease (HD) is neurodegenerative disease caused by a CAG repeat expansion mutation in the HTT gene.
The pathological process, which ultimately leads to neuronal loss mainly in the caudate and putamen, is induced - in a truly dominant manner - by a single copy of the mutant allele.
Transcriptional deregulation has becoming a prevailing feature in HD and changes at single-gene level in RNA biogenesis and aberrant alternative splicing (AS) events have been associated to neuronal vulne…
UNIVERSITA DEGLI STUDI DI TRENTO
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