CORDIS Project
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This project investigates how different cell types manage protein folding and quality control, focusing on the role of transfer RNA in translation speed. By studying stem cells and their differentiated forms, it aims to uncover mechanisms that maintain protein homeostasis and the varying resilience of cells to misfolde…
Proteins function only after folding into complex three-dimensional shapes.
Loss of protein conformation is detrimental for cellular health, and a hallmark of aging and diverse human diseases.
To ensure proteome integrity, cells rely on an intricate interplay between protein synthesis, folding, and quality control.
Since proteins often begin to fold during mRNA translation, codon choice and tRNA supply can promote this process by modulating translation speed.
How metazoans exploit this mechanism…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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