CORDIS Project
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This project aims to enhance CAR T cell therapy for solid tumors by using genetically modified immune cells as delivery vehicles to activate CAR T cells in the tumor microenvironment. By engineering hematopoietic stem cells, the project seeks to overcome immunosuppression and improve tumor recognition, focusing on mela…
Two major issues hamper successful treatment of solid cancers with CAR T cells.
First, immunosuppression imposed by the tumor microenvironment (TME) can compromise CAR T cell function.
Second, CAR T cells require specific antigens for precise tumor recognition to limit/avoid toxicities associated with on-target/off-tumor activity.
Initial attempts to overcome these challenges included immune checkpoint blockade and tunable CAR T cells.
Here, we propose to develop a conceptually new framework for…
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