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TrapKill aims to enhance glioblastoma treatment by developing a specialized hydrogel that manipulates cancer cell behavior. This innovative approach combines mechanical and chemical strategies to improve the effectiveness of existing therapies against aggressive brain tumors.
Glioblastoma Multiforme(GB) is an aggressive brain cancer associated with a 2% 5-year survival rate and 250,000 new diagnoses globally.Gold standard treatment includes surgical resection and radiotherapy coupled with Temozolomide(TMZ) chemotherapy that promote cancer cell death.Resistance to TMZ and radiotherapy develops rapidly due to DNA repair mechanisms, indicating that targeted disruption of them can potentiate these therapies.
TrapKill combines cancer mechanobiology, microfabrication and b…
UNIVERSITY OF GALWAY
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