CORDIS Project
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This project focuses on overcoming CD8 T-cell exhaustion in cancer immunotherapy, which limits treatment effectiveness. By exploring the biology of a newly identified subset of exhausted T-cells, the research aims to develop innovative strategies to enhance the efficacy of existing therapies, particularly those targeti…
Cancer Immunotherapy has revolutionized Clinical Oncology.
Yet, CD8 T-cell exhaustion remains a leading cause of treatment failure.
This hypofunctional program suppresses anti-tumor CD8 T-cell responses and is reinforced by a stable epigenetic program that prevents exhausted CD8 T-cells (Tex) from reverting to more functional states.
Checkpoint inhibitors such as anti-PD-1 can temporally relieve some constraints on TEX and be curative.
However, this approach alone does overcome the epigenetic re…
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