CORDIS Project
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This project explores the use of a viral vector for targeted delivery of interleukin-2 to the brain, aiming to mitigate inflammation in neuroinflammatory diseases. It builds on previous findings to enhance regulatory T cell populations and prevent neurological damage.
A proposal to use local IL2 delivery via a viral vector to prevent and reverse the inflammatory damage that happens to the brain during neuroinflammatory diseases as diverse as traumatic brain injury, Multiple Sclerosis and Alzheimer's Disease.
In ""TissueTregs"" we identified and characterised a brain-resident regulatory T cell population, with high expression of anti-inflammatory and reparative proteins. A synthetic circuit for deliver IL2 to the brain expanded this population, without any off…
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