CORDIS Project
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This project focuses on developing a targeted cancer therapy using synthetic double-stranded RNA to combat cancers that overexpress the epidermal growth factor receptor. The approach aims to induce cell death in tumors while minimizing effects on healthy tissue.
We have recently shown that application of EGFR targeted synthetic dsRNA:
Poly Iosine/Poly Cytosine (pIC) is highly efficient and selective against deadly cancers overexpressing EGFR, like glioblastoma (U87MGwtEGFR), breast cancer (MDA-MB-468) and adenocarcinoma (A431).
Double-stranded RNA, frequently expressed in cells infected with viruses, activates a number of pro-apoptotic processes simultaneously.
These dsRNA-induced mechanisms efficiently kill infected cells and induce expression of anti-…
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