CORDIS Project
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This project investigates the role of regulatory T cells in preventing acute graft-versus-host disease following stem cell transplantation. It aims to understand T cell subpopulations and their potential plasticity, which could lead to better treatment strategies for patients.
Allogeneic hematopoietic stem cell transplantation (HSCT) is an increasingly used intensive therapy to treat patients with hematological malignancies and other life-threatening hematological and genetic diseases.
Acute graft-versus-host disease (aGVHD) is the main complication of HSCT and an important cause of mortality.
Cellular therapy with CD4+FOXP3+ regulatory T cells (Treg), a population with potent immunosuppressive properties, has proven highly effective in mouse models of GVHD; however,…
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