CORDIS Project
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This project aims to enhance the understanding of tissue-resident regulatory T cells, which are crucial for controlling inflammation. By decoding the signals that enable these cells to enter tissues, it seeks to improve cell therapy for inflammatory diseases.
Foxp3+ regulatory T cells (Tregs) are highly potent immunosuppressive cells.
Most of our understanding of Tregs is based on the population present in lymphoid tissues, however to harness their anti-inflammatory power in the clinic we need to understand the tissue-resident population.
Converting generic Tregs into expanded proto-tissue Tregs, capable of entering inflamed tissues, adapting to local conditions, and driving an anti-inflammatory pro-rejuvenation process would transform cell therapy.…
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