CORDIS Project
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This research focuses on developing alternative antibiotics for treating treponematoses, including syphilis and yaws, due to the limitations of penicillin. It aims to identify effective drugs with good central nervous system penetration and evaluate their efficacy through clinical trials.
Current therapeutic options for human treponematoses, syphilis and yaws, are, broadly speaking, restricted to one antibiotic: injectable penicillin.
The drug susceptibility profile of Treponema pallidum (T.p) is unknown because the microorganism could not be grown in culture.
Treatment failure after penicillin has been related to syphilis bacteria that survive in the central nervous system (CNS) and the potential of strains to acquire resistance to penicillin has recently been recognized.
Yaws c…
FUNDACION FLS DE LUCHA CONTRA ELSIDA LAS ENFERMEDADES INFECCIOSASY LA PROMOCION DE LA SALUD Y LACIENCIA
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United States, Seattle Wa
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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